A practical chemoenzymatic synthesis of a key intermediate of antifungal agents

✍ Scribed by Yoshihiko Yasohara; Kenji Miyamoto; Noriyuku Kizaki; Junzo Hasegawa; Takehisa Ohashi

• Book ID: 104230494
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 56 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00425-7

✦ Synopsis

A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.