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Catalytic Enantioselective Synthesis of Key Intermediates for Triazole Antifungal Agents

โœ Scribed by Suzuki, Masato; Kato, Nobuki; Kanai, Motomu; Shibasaki, Masakatsu

Book ID
120802705
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
111 KB
Volume
7
Category
Article
ISSN
1523-7060

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A novel synthesis of an azole antifungal building block, the optically active diol, is described. The key step involves an enantioselective hydrolysis of a prochiral diester by a lipase.