A recombinant clone was isolated containing a sequence which occurs only on human chromosome 21 and defines a two-allele restriction fragment length polymorphism showing Mendelian inheritance. Forty seven percent of the London population are heterozygous for the polymorphism. The chromosomal locatio
A possible cause of non-disjunction of additional chromosome 21 in Down syndrome
โ Scribed by Verma, Ram S. ;Babu, Arvind ;Chemitiganti, Sundari ;Dosik, Harvey
- Publisher
- Springer
- Year
- 1986
- Tongue
- English
- Weight
- 704 KB
- Volume
- 202
- Category
- Article
- ISSN
- 0026-8925
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The relative roles of Meiosis I and Meiosis II non-disjunctions in the causation of trisomy 21 have been assessed by analysing the distribution of polymorphic phenotypes of the chromosomes 21 in a group of individuals with Down's syndrome. The data suggest that the majority of cases of trisomy 21 ar
Six series of patients with Down syndrome (DS) from different European countries, altogether 287 cases, were divided into four categories according to parental origin of the additional chromosome 21 and meiotic division in which the nondisjunction had occurred. The monthly birth or conception freque