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Meiosis I non-disjunction as the main cause of trisomy 21

โœ Scribed by Jacqueline A. Robinson

Publisher
Springer
Year
1977
Tongue
English
Weight
162 KB
Volume
39
Category
Article
ISSN
0340-6717

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โœฆ Synopsis

The relative roles of Meiosis I and Meiosis II non-disjunctions in the causation of trisomy 21 have been assessed by analysing the distribution of polymorphic phenotypes of the chromosomes 21 in a group of individuals with Down's syndrome. The data suggest that the majority of cases of trisomy 21 are due to meiosis I non-disjunctions.

๐Ÿ“œ SIMILAR VOLUMES

Evidence for the repeated primary non-di
Evidence for the repeated primary non-disjunction of chromosome 21 as a result of premature centromere division (PCD)
โœ P. H. Fitzgerald; Susan A. Archer; Christine M. Morris ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Springer ๐ŸŒ English โš– 578 KB

A clinically normal 28-year-old woman had three conceptuses with trisomy 21 and one normal child. She showed minimal cytogenetic evidence of mosaicism: 4% of her blood cells and 6% of skin fibroblasts had trisomy 21. Also, 7% of her blood cells showed aneuploidy of the X chromosome which was associa