A mechanistic model for the enantioselective addition of diethylzinc to benzaldehyde with chiral tridentate lithium complexes as catalysts correctly predicts the observed direction of enantioselectivity which occurs at levels of 8595% ee. A recent paper from these laboratories described two rationa
A Positional Scanning Approach to the Discovery of Dipeptide-Based Catalysts for the Enantioselective Addition of Vinylzinc Reagents to Aldehydes.
β Scribed by Christopher M. Sprout; Meaghan L. Richmond; Christopher T. Seto
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 39 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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Optically active set-alcohols in 90% enantiomeric excess were obtained from the enantioselective addition of dialkyl zincs to aryl aldehydes in the presence of a catalytic amount of dilithium salt of (2S, 52)-2, 5diisopropylpiperazine. Chiral piperazine (cyclic diamine) has rarely been utilized as c
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