Chiral piperazine as a new chiral catalyst for the enantioselective addition of dialkyl zincs to aryl aldehydes

✍ Scribed by Kenso Soai; Seiji Niwa; Yasuyuki Yamada; Hideo Inoue

• Publisher: Elsevier Science
• Year: 1987
• Tongue: French
• Weight: 148 KB
• Volume: 28
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)96639-5

✦ Synopsis

Optically active set-alcohols in 90% enantiomeric excess were obtained from the enantioselective addition of dialkyl zincs to aryl aldehydes in the presence of a catalytic amount of dilithium salt of (2S, 52)-2, 5diisopropylpiperazine. Chiral piperazine (cyclic diamine) has rarely been utilized as chiral auxiliary in asymmetric reactions.' On the other hand, catalytic asymmetric induction in carbon-carbon bond forming reaction is one of the most important