A physiologically based pharmacokinetic model for valnemulin in rats and extrapolation to pigs
β Scribed by L. G. YUAN; X. Y. LUO; L. X. ZHU; R. WANG; Y. H. LIU
- Book ID
- 108885553
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 335 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0140-7783
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract A physiologically based pharmacokinetic (PBPK) model for simulating the kinetics of cyclotrimethylene trinitramine (RDX) in male rats was developed. The model consisted of five compartments interconnected by systemic circulation. The tissue uptake of RDX was described as a perfusionβlim
Antibodies directed against tumor associated antigens are being increasingly used for detection and treatment of cancers; however, there is an incomplete understanding of the physiological determinants of antibody pharmacokinetics and tumor distribution. The purpose of this study is to (a) compare t