A phase I/II dose-escalation study of exisulind and docetaxel in patients with hormone-refractory prostate cancer
β Scribed by Christopher W. Ryan; Walter M. Stadler; Nicholas J. Vogelzang
- Book ID
- 109051748
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 101 KB
- Volume
- 95
- Category
- Article
- ISSN
- 1464-4096
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## Abstract ## BACKGROUND Docetaxel has significant singleβagent activity in patients with prostate carcinoma, and ketoconazole has activity as a secondβline hormonal agent. In vitro, ketoconazole exhibits synergy with several chemotherapeutic agents. A potential drug interaction exists, however,