Docetaxel and ketoconazole in advanced hormone-refractory prostate carcinoma : A phase I and pharmacokinetic study

✍ Scribed by Peter J. Van Veldhuizen; Gregory Reed; Arvind Aggarwal; Joaquina Baranda; Muhammad Zulfiqar; Stephen Williamson

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: English
• Weight: 91 KB
• Volume: 98
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/cncr.11733

✦ Synopsis

Abstract

BACKGROUND

Docetaxel has significant single‐agent activity in patients with prostate carcinoma, and ketoconazole has activity as a second‐line hormonal agent. In vitro, ketoconazole exhibits synergy with several chemotherapeutic agents. A potential drug interaction exists, however, because both docetaxel and ketoconazole are metabolized hepatically by the cytochrome p450 system (CYP3A4). The authors performed a Phase I study and a pharmacokinetic study evaluating the both tolerability of a docetaxel/ketoconazole combination as well as this potential drug interaction.

METHODS

For all initial patients, docetaxel was administered intravenously at a dose of 55 mg/m^2^ over 1 hour every 21 days. Starting on Day 8 after their first docetaxel dose, cohorts of at least 3–5 new patients were enrolled to receive escalating doses of ketoconazole. When the maximally tolerated dose (MTD) of ketoconazole was reached, the subsequent cohort of patients received an escalating dose of docetaxel. Pharmacokinetic studies were performed after docetaxel infusions on Day 1 (prior to ketoconazole) and Day 22 (after starting ketoconazole).

RESULTS

Twenty‐six patients were enrolled and completed at least 2 cycles of treatment. The MTD was ketoconazole 400 mg twice daily and docetaxel 55 mg/m^2^. Dose‐limiting toxicities included neutropenia and fatigue. Ketoconazole did not cause a consistent effect on docetaxel pharmacokinetics, although there was significant intrapatient and interpatient variability in serum levels.

CONCLUSIONS

The recommended Phase II dose for this combination is ketoconazole 400 mg twice daily and docetaxel 55 mg/m^2^ every 21 days. Cancer 2003. Published 2003 by the American Cancer Society.