A phase II study of UCN-01 in combination with irinotecan in patients with metastatic triple negative breast cancer
β Scribed by Cynthia X. Ma, Matthew J. C. Ellis, Gina R. Petroni, Zhanfang Guo, Shi-rong Cai, Christine E. Ryan, A. Craig Lockhart, Michael J. Naughton, Timothy J. Pluard, Christiana M. Brenin, Joel Picus, Allison N. Creekmore, Tibu Mwandoro, Erin R. Yarde, Jerry Reed, et al
- Book ID
- 118796856
- Publisher
- Springer US
- Year
- 2012
- Tongue
- English
- Weight
- 466 KB
- Volume
- 137
- Category
- Article
- ISSN
- 0167-6806
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## Purpose UCN-01 (7-hydroxystaurosporine) is a multi-targeted protein kinase inhibitor that exhibits synergistic activity with DNA-damaging agents in preclinical studies. We conducted a Phase I study to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic, and
Nearly half of patients with advanced triple negative breast cancer (TNBC) develop brain metastases (BM) and most will also have uncontrolled extracranial disease. This study evaluated the safety and efficacy of iniparib, a small molecule anti-cancer agent that alters reactive oxygen species tumor m