๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

430 Phase I and pharmacokinetic study of UCN-01 (U) in combination with irinotecan (I) in patients with solid tumors

โœ Scribed by A. Jimeno; M.A. Rudeck; W.T. Purcell; Y. Zabelina; K. Elza-Brown; T. Rogers; J.E. Dancey; S.D. Baker; M. Carducci; R. Donehower

Book ID
118621613
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
145 KB
Volume
2
Category
Article
ISSN
1359-6349

No coin nor oath required. For personal study only.

๐Ÿ“œ SIMILAR VOLUMES

A Phase 1 study of UCN-01 in combination
A Phase 1 study of UCN-01 in combination with irinotecan in patients with resistant solid tumor malignancies
โœ Paula M. Fracasso; Kerry J. Williams; Ronald C. Chen; Joel Picus; Cynthia X. Ma; ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› Springer ๐ŸŒ English โš– 451 KB

## Purpose UCN-01 (7-hydroxystaurosporine) is a multi-targeted protein kinase inhibitor that exhibits synergistic activity with DNA-damaging agents in preclinical studies. We conducted a Phase I study to determine the maximum-tolerated dose (MTD), dose-limiting toxicity (DLT), pharmacokinetic, and