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A phase I trial of Depsipeptide (FR901228) in patients with advanced cancer

✍ Scribed by John L. Marshall; Naiyer Rizvi; John Kauh; William Dahut; Manuela Figuera; Min H. Kang; William D. Figg; Irving Wainer; Christoff Chaissang; Megan Zhaoyang Li; Michael J. Hawkins

Book ID
114424688
Publisher
Wiley (Blackwell Publishing)
Year
2002
Tongue
English
Weight
145 KB
Volume
2
Category
Article
ISSN
1533-869X

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Adenosine 5'-triphosphate (ATP) has antineoplastic activity in vitro and in murine tumor systems, but there are no data in humans defining its potential use as an antineoplastic agent. We conducted a Phase I study to determine the spectrum of toxicity, maximum safely tolerated dose (MTD), and pharma