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A Phase I trial of B-cell depletion with anti-CD20 monoclonal antibody (rituximab) in the treatment of systemic lupus erythematosus

✍ Scribed by R Eisenberg, D Albert, J Stansberry, D Tsai, S Kolasinski, S Khan


Book ID
120708091
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
554 KB
Volume
5
Category
Article
ISSN
1478-6354

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## Abstract ## Objective Safer and more effective therapies are needed for the treatment of systemic lupus erythematosus (SLE). B lymphocytes have been shown to play fundamental pathogenic roles in SLE, and therefore, elimination of B cells with the use of rituximab may represent a new therapy for