## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEGβLD) and gemcitabine have singleβagent activity in breast and ovarian carcinoma patients. We conducted a Phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in patients with advanced malignancie
A phase I study of pegylated liposomal doxorubicin and temsirolimus in patients with refractory solid malignancies
β Scribed by Wang-Gillam, Andrea; Thakkar, Nilay; Lockhart, A. Craig; Williams, Kerry; Baggstrom, Maria; Naughton, Michael; Suresh, Rama; Ma, Cynthia; Tan, Benjamin; Lee, Wooin; Jiang, Xuntian; Mwandoro, Tibu; Trull, Lauren; Belanger, Stefanie; Creekmore, Allison N.; Gao, Feng; Fracasso, Paula M.; Picus, Joel
- Book ID
- 125344330
- Publisher
- Springer
- Year
- 2014
- Tongue
- English
- Weight
- 282 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEGβLD) and docetaxel have singleβagent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with ad