## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and gemcitabine have single‐agent activity in breast and ovarian carcinoma patients. We conducted a Phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in patients with advanced malignancie
✦ LIBER ✦
A phase I and pharmacologic study of the combination of bortezomib and pegylated liposomal doxorubicin in patients with refractory solid tumors
✍ Scribed by E. Claire Dees; Bert H. O’Neil; Celeste M. Lindley; Frances Collichio; Lisa A. Carey; Jason Collins; William J. Riordan; Anastasia Ivanova; Dixie Esseltine; Robert Z. Orlowski
- Publisher
- Springer
- Year
- 2008
- Tongue
- English
- Weight
- 527 KB
- Volume
- 63
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEG‐LD) and docetaxel have single‐agent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with ad