A phase I study of intermittent infusion cladribine in patients with solid tumors
β Scribed by Ken Kobayashi; Nicholas J. Vogelzang; Sheila M. O'Brien; Richard L. Schilsky; Everett E. Vokes; Mark J. Ratain
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 621 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
A Phase I study was initiated to determine the maximum tolerated dose of weekly gemcitabine combined with monthly, fixed-dose docetaxel. ## METHODS. Patients with metastatic solid tumors were treated with docetaxel, 60 mg/m 2 , on Day 1 every 28 days. Gemcitabine was administered on Days 1, 8, and
## Abstract To determine the maximum tolerated dose of 5βfluorouracil administered as a 120βhour continuous intravenous infusion to pediatric patients, we performed a phase I study using a starting dosage of 900 mg/m^2^/day. The maximum tolerated dosage (MTD) was 1,100 mg/m^2^/day. At this dosage l
## Abstract ## BACKGROUND 9βNitrocamptothecin (9βNC) is an orally available camptothecin analog with antineoplastic activity that results from the inhibition of DNA topoisomerase I. Previous studies have suggested that it has significant clinical efficacy. The primary toxicities of 9βNC include ga