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A pH-tunable peptide ligase

✍ Scribed by Shao Yao; Jean Chmielewski

Publisher
Wiley (John Wiley & Sons)
Year
1999
Tongue
English
Weight
122 KB
Volume
51
Category
Article
ISSN
0006-3525

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✦ Synopsis

A chemical ligation system is reported, in which a highly acidic coiled-coil peptide was used to template two basic peptide fragments and catalyze their condensation, in a pH-tunable fashion, to generate a coiled-coil product. This template showed a high catalytic efficiency (with single turnover) under neutral conditions. Under acidic conditions, however, its catalytic efficiency was reduced by approximately 4500-fold.

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