A pH-tunable peptide ligase
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Shao Yao; Jean Chmielewski
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Article
📅
1999
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Wiley (John Wiley & Sons)
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English
⚖ 122 KB
A chemical ligation system is reported, in which a highly acidic coiled-coil peptide was used to template two basic peptide fragments and catalyze their condensation, in a pH-tunable fashion, to generate a coiled-coil product. This template showed a high catalytic efficiency (with single turnover) u