✦ LIBER ✦

Novel pH- and Temperature-Responsive Block Copolymers with Tunable pH-Responsive Range

✍ Scribed by Chaoliang He; Changwen Zhao; Xuesi Chen; Zhaojun Guo; Xiuli Zhuang; Xiabin Jing

Publisher: John Wiley and Sons
Year: 2008
Tongue: English
Weight: 200 KB
Volume: 29
Category: Article
ISSN: 1022-1336
DOI: 10.1002/marc.200700721

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✦ Synopsis

Abstract

A series of novel pH‐ and temperature‐responsive diblock copolymers composed of poly(N‐isopropylacrylamide) (PNIPAM) and poly[(L‐glutamic acid)‐co‐(γ‐benzyl L‐glutamate)] [P(GA‐co‐BLG)] were prepared. The influence of hydrophobic benzyl groups on the phase transition of the copolymers was studied for the first time. With increasing BLG content in P(GA‐co‐BLG) block, the thermal phase transition of the diblock copolymer became sharper at a designated pH and the critical curve of phase diagram of the diblock copolymer shifted to a higher pH region. Notably, when the BLG content in P(GA‐co‐BLG) block was more than 30 mol.‐%, the diblock copolymer responded sharply to a narrow pH change in the region of pH 7.4–5.5.

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