pH-Responsive PEG-Poly(β-amino ester) Block Copolymer Micelles with a Sharp Transition
✍ Scribed by Min Sang Kim; Su Jong Hwang; Jong Kwon Han; Eun Kyung Choi; Heon Joo Park; Jin Seok Kim; Doo Sung Lee
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- English
- Weight
- 132 KB
- Volume
- 27
- Category
- Article
- ISSN
- 1022-1336
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✦ Synopsis
Abstract
Summary: A pH‐sensitive block copolymer is synthesized by step polymerization and its pH‐sensitive micellization‐demicellization behavior is studied. This polymer has a hydrophilic MPEG (shell) and hydrophobic but pH‐sensitive poly(β‐amino ester) (core), which can form a self‐assembled micelle. As confirmed by fluorescence spectroscopy and dynamic light scattering (DLS), this polymer shows a sharp pH‐sensitive micellization‐demicellization behavior. It is confirmed that the pH sensitivity is affected by the molecular weight ratio between the MPEG and poly(β‐amino ester).
Plots of the intensity ratio I~337~/I~334~ (from pyrene excitation spectra): a) vs. pH for copolymer samples and b) vs. log (concentration) for M1.
magnified imagePlots of the intensity ratio I~337~/I~334~ (from pyrene excitation spectra): a) vs. pH for copolymer samples and b) vs. log (concentration) for M1.