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A Ph-negative Chronic Myeloid Leukemia Patient with a Non-classical BCR-ABL Rearrangement Characterized by Fluorescence In Situ Hybridization

✍ Scribed by A.M Estop; C Sherer; K Cieply; D Groft; A Burcoglu; S Jhanwar; J Thomas


Book ID
114136149
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
242 KB
Volume
96
Category
Article
ISSN
0165-4608

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The t(9;22) translocation resulting in the fusion of BCR and ABL genes is pathognomonic in chronic myeloid leukemia (CML) and may be investigated at the molecular level using fluorescence in situ hybridization (FISH). Two-color BCR-ABL probes visualizing one fusion signal (1F FISH) have high false p