The Abl/bcr Fusion Gene on Chromosome 9 in Ph-Negative Chronic Myelogenous Leukemia: A Case for Vigilance in Fluorescence In Situ Hybridization Interpretation
β Scribed by Wei-Tong Hsu; Harvey Preisler; Katarina Szego; Rita Sprudzs; Xue-Zhi Gao
- Book ID
- 114136418
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 421 KB
- Volume
- 104
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Fluorescence in situ hybridization for the __BCR__/__ABL__ rearrangement in 138 bone marrow specimens from 59 Philadelphia^+^ (Ph^+^) chronic myelogenous leukemia (CML) patients, 35 Ph^+^ acute lymphoblastic leukemia (ALL) patients, and 57 Ph^β^ ALL patients was used. Sixteen (27.1%) of
Two new variant Philadelphia (Ph) chromosomes with an aberrant location of the BCR-ABL fusion gene on 9q34 of the derivative 9 are reported. One presented cytogenetically as a standard t(9;22)(q34;q11), whereas the other was classified as an ins(9;22)(q34;q11.1q11.2) using the combined interpretatio