Near-haploid blast phase in a chronic myeloid leukemia detected by fluorescence in situ hybridization using a BCR-ABL probe
β Scribed by David Gancberg; Jean-Louis Dargent; Alain Verhest; Alain Kentos; Walter Feremans; Caroline Lohrisch; Anne Kornreich
- Book ID
- 114135075
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 107 KB
- Volume
- 128
- Category
- Article
- ISSN
- 0165-4608
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The t(9;22) translocation resulting in the fusion of BCR and ABL genes is pathognomonic in chronic myeloid leukemia (CML) and may be investigated at the molecular level using fluorescence in situ hybridization (FISH). Two-color BCR-ABL probes visualizing one fusion signal (1F FISH) have high false p
## Abstract Loss of the Y chromosome in bone marrow (BM) cells is a normal ageβassociated event. Y chromosome loss is also observed in the Philadelphia chromosome (Ph) positive BM cells of some patients with chronic myeloid leukemia (CML) in chronic phase, but at a younger age than in normal indivi