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A one-pot synthesis of 1-arylalka-1,3-diynes by sequential acetylene zipper and Sonogashira reactions

✍ Scribed by Irina A. Balova; Svetlana N. Morozkina; David W. Knight; Sergei F. Vasilevsky

Publisher
Elsevier Science
Year
2003
Tongue
French
Weight
129 KB
Volume
44
Category
Article
ISSN
0040-4039

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✦ Synopsis

1,3-Diynes, formed in situ by base-induced acetylene zipper reactions, following anion quenching with water, undergo smooth Sonogashira-type couplings with functionalized aryl iodides, to give good overall yields of 1-arylalka-1,3-diynes.

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