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A One-Pot Preparation of 1,3-Disubstituted Azetidines

✍ Scribed by Hillier, Michael C.; Chen, Cheng-yi

Book ID
125507687
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
65 KB
Volume
71
Category
Article
ISSN
0022-3263

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Chiral C 2 -symmetric N-benzylazetidines have been conveniently prepared from optically pure anti-1,3-diols without loss of enantiomeric purity. N-Debenzylation led to the corresponding N-unsubstituted azetidines, which were then subjected to palladium-catalysed coupling reactions with aryl [a]