A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
β Scribed by Wang, Yingfei (author);An, Ran (author);Umanah, George K (author);Park, Hyejin (author);Nambiar, Kalyani (author);Eacker, Stephen M (author);Kim, Bongwoo (author);Bao, Lei (author);Harraz, Maged M (author);Chang, Calvin (author);Chen, Rong (author);Wang, Jennifer E (author);Kam, Tae-In (author);Jeong, Seop (author);Xie, Zhi (author);Neifert, Stewart (author);Qian, Jiang (author);Andrabi, Shaida A (author);Blackshaw, Seth (author);Zhu, Heng (author);Song, Hongjun (author);Ming, Guo-Li (author);Dawson, Valina L (author);Dawson, Ted M (author)
- Book ID
- 119983255
- Weight
- 402 KB
- Category
- Article
- DOI
- 10.1126/science
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Poly(ADP-ribose) polymerase (PARP) is a DNA-bind-induced apoptosis. After VP16 treatment with PARP ing protein involved in cellular response to various inhibition, a reduction in the depletion of the prolifgenotoxic agents. To understand the role of PARP erative compartment and a G2/M phase arrest a