DNA damage and cytotoxicity induced by β-lapachone: relation to poly(ADP-ribose) polymerase inhibition
✍ Scribed by Antonella Vanni; Mario Fiore; Rosella De Salvia; Enrico Cundari; Ruggero Ricordy; Roberto Ceccarelli; Francesca Degrassi
- Book ID
- 114071467
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 325 KB
- Volume
- 401
- Category
- Article
- ISSN
- 0027-5107
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📜 SIMILAR VOLUMES
Poly(ADP-ribose) polymerase (PARP) is a DNA-bind-induced apoptosis. After VP16 treatment with PARP ing protein involved in cellular response to various inhibition, a reduction in the depletion of the prolifgenotoxic agents. To understand the role of PARP erative compartment and a G2/M phase arrest a
The activity of poly(ADP-ribose) polymerase (PARP) is activated upon recognition of DNA strand breaks by its DNA-binding domain and the stimulation of this nuclear enzyme seems to be an early response of cells exposed to a variety of different DNA-damaging agents. In the present work we evaluate the