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Oxidative stress initiates DNA damager MNNG-induced poly(ADP-ribose)polymerase-1-dependent parthanatos cell death

✍ Scribed by Ling-Ya Chiu; Feng-Ming Ho; Shine-Gwo Shiah; Yung Chang; Wan-Wan Lin

Book ID: 113489407
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 766 KB
Volume: 81
Category: Article
ISSN: 0006-2952
DOI: 10.1016/j.bcp.2010.10.016

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## Abstract Continuously generated hydrogen peroxide (H~2~O~2~) inhibits typical apoptosis and instead initiates a caspase‐independent, apoptosis‐inducing factor (AIF)‐mediated pyknotic cell death. This may be related to H~2~O~2~‐mediated DNA damage and subsequent ATP depletion, although the exact