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A novel three-step synthesis of a pyrrolo[3,2-d]pyrimidine C-nucleoside

โœ Scribed by Cupps, Thomas L.; Wise, Dean S.; Townsend, Leroy B.


Book ID
126262522
Publisher
American Chemical Society
Year
1986
Tongue
English
Weight
954 KB
Volume
51
Category
Article
ISSN
0022-3263

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Synthesis of furo[3,2-d]pyrimidine nucle
โœ Birendra K. Bhattacharya; Mu-Ill Lim; Brian A. Otter; Robert S. Klein ๐Ÿ“‚ Article ๐Ÿ“… 1986 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 234 KB

The synthesis of 4-amino-7-(8-D-ribofuranosyl)-furoC3.2-dlpyrimidine, a new Cnucleoside analog of adenosine. is described. It involves base-catalyzed cyclization of the 2-(ribofuranosyl)-t-cyan0 ethers 3 to afford the ribosyl-3-amino-2-cyanofurans 4a and 48. followed by a two step conversion into th