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A novel synthetic approach to the preparation of various α,α-difluoroesters

✍ Scribed by Sylvia Bildstein; Jean-Bernard Ducep; Detlef Jacobi

Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
170 KB
Volume
37
Category
Article
ISSN
0040-4039

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✦ Synopsis

Treatment of readily available ¢t-fluoro-l~hydroxy-Ct-phenylthioesters 4 with DAST afforded ct,ct-difluoro-[~-phenylthioesters 6 which are of interest to synthesize gem-difluorinated derivatives.

📜 SIMILAR VOLUMES

ChemInform Abstract: A Novel Synthetic A
ChemInform Abstract: A Novel Synthetic Approach to the Preparation of Various α,. alpha.-Difluoroesters.
✍ S. BILDSTEIN; J.-B. DUCEP; D. JACOBI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 1 views

A Novel Synthetic Approach to the Preparation of Various α,. alpha.-Difluoroesters. -Successive condensation of ethyl bromofluoroacetate with thiophenol and aldehydes provides α-fluoro-β-hydroxy-α-phenylthio esters (I). Treatment of these esters with exception of (Id) with DAST yields rearranged α,