Treatment of readily available ¢t-fluoro-l~hydroxy-Ct-phenylthioesters 4 with DAST afforded ct,ct-difluoro-[~-phenylthioesters 6 which are of interest to synthesize gem-difluorinated derivatives.
A novel synthetic approach to α-alkylidene-α-lactams
✍ Scribed by Benito Alcaide; Joaquin Plumet; Julián Rodríguez-López; Yolanda M. Sánchez-Cantalejo
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- French
- Weight
- 245 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
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## Abstract An operationally simple and efficient approach for the synthesis of novel spiro‐β‐lactams is described. The key reaction is a halogen‐mediated intrasulfenyl cyclization of a __cis__‐3‐benzylthio‐3‐(prop‐2‐ynyloxy/‐enyloxy)‐β‐lactam procured through a Lewis acid‐mediated C‐3‐alkylation o
A convenient simple route to N-unsubstituted B-lactams is described. Formation of unusual N-styryl--B-lactams is the key of the method. Synthesis of N-unsubstituted B-lactams have received increased attention in the past few years and specially with the advent of the third generation of 8-lactam ant