## Reaction of sterically crowded achiral 3-(2-bromopropionyl)-2-oxazolidone derivatives with (3R,4R)-4-acetoxy-3-[(fl)-l-(t-butyldimethylsilyloxy)ethyl]-2-azetidinone
A novel synthesis of the 1β-methylcarbapenem key intermediate employing the [2+2]-cycloaddition reaction of chlorosulfonyl isocyanate with a 4H-1,3-dioxin derivative
✍ Scribed by Yoshio Ito; Yuko Kobayashi; Shiro Terashima
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- French
- Weight
- 332 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The reaction of 3-substituted-4-hydroxyroxy-2H-1,2-be~othiazine 1,l-dioxides with aryl isocyanate under different equivalents of strong base NaH was studied. Seventeen of new derivatives were obtained whose structures were characterized by ' H NMR, IR, MS, elementary analysis and FeCls test. ## Key
## Abstract magnified image A simple one‐step method for preparation of novel 1,3,4‐triaryl‐3,4‐dihydropyrimidin‐2(1__H__)‐ones has been developed by reaction of aromatic isocyanates with β‐arylamino‐1‐phenylpropan‐1‐ones in refluxing toluene in the presence of KHSO~4~ and HCl.
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