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Synthesis of Novel 1,2,3-4-Tetrahydroisoquinoline-3-carboxylic Acid Derivatives Through the Application of Rongalite: A Synergistic Combination of [2 + 2 + 2]- and [4 + 2]-Cycloaddition Reactions.

✍ Scribed by Sambasivarao Kotha; Shaibal Banerjee


Publisher
John Wiley and Sons
Year
2007
Weight
31 KB
Volume
38
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.


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Synthesis of 1,2,3,4-Tetrahydroisoquinol
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A new and general synthetic methodology for the preparation of functionalized 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives by a cycloaddition strategy is described. The synthesis of various enyne building blocks 12, 13, 21, and 22 containing an Ξ±-amino acid moiety using Schiff base 8

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