A novel synthesis of spironolactone. An application of the hydroformylation reaction
β Scribed by Wuts, Peter G. M.; Ritter, Allen R.
- Book ID
- 121307000
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 480 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
2',3'-Dideoxy-3'-hydroxymethylcytidine (1) has been synthesized via stereoseleetive Rhcatalyzed hydroformylation of 2',3'-didehydro-2',3'-dideoxycytidine 3b. This synthesis incorporates the first successful hydroformylation of a nucleoside olefin.
The temporary incorporation of a coordinatin the tetracyclic phyllanthocin precursor la directed the [(C '8 hosphine residue (~-(PhzP)C6~Co~ into ~)RhOAclz-catalyzed hydroformylation of Id largely to the desired C( 3) position. This ~i~~~olec~lar h drofo~ylation" strategy substantially improves a ke
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