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Intramolecular phosphine-directed hydroformylation. Application to the total synthesis of (+)-phyllanthocin

✍ Scribed by Steven D. Burke; Jeffery E. Cobb

Publisher
Elsevier Science
Year
1986
Tongue
French
Weight
291 KB
Volume
27
Category
Article
ISSN
0040-4039

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✦ Synopsis

The temporary incorporation of a coordinatin the tetracyclic phyllanthocin precursor la directed the [(C '8 hosphine residue (~-(PhzP)C6~Co~ into ~)RhOAclz-catalyzed hydroformylation of Id largely to the desired C( 3) position. This ~i~~~olec~lar h drofo~ylation" strategy substantially improves a key ~ansfo~ation in the total synthesis of ( + )-phyl antbocin. !

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