Asymmetric Synthesis of (S)-5,5,5,5′,5′,
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Cong Zhang; Christian Ludin; Marcel K. Eberle; Helen Stoeckli-Evans; Reinhart Ke
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Article
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1998
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John Wiley and Sons
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German
⚖ 572 KB
## Abstract (__S__)‐5,5,5,5′,5′,5′‐Hexafluoroleucine ((__S__)‐13) of 81 % ee is prepared from hexafluoroacetone (l) and ethyl bromopyruvate (= ethyl 2‐oxopropanoate) in 7 steps with an overall yield of 18% (__Schemes 1__ and __2__). Key step in this sequence is the highly enantioselective reduction