𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A Novel Synthesis of Enantiomerically Pure 5,5,5,5‘,5‘,5‘-Hexafluoroleucine

✍ Scribed by Xing, Xuechao; Fichera, Alfio; Kumar, Krishna


Book ID
126130717
Publisher
American Chemical Society
Year
2001
Tongue
English
Weight
28 KB
Volume
3
Category
Article
ISSN
1523-7060

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Asymmetric Synthesis of (S)-5,5,5,5′,5′,
✍ Cong Zhang; Christian Ludin; Marcel K. Eberle; Helen Stoeckli-Evans; Reinhart Ke 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 German ⚖ 572 KB

## Abstract (__S__)‐5,5,5,5′,5′,5′‐Hexafluoroleucine ((__S__)‐13) of 81 % ee is prepared from hexafluoroacetone (l) and ethyl bromopyruvate (= ethyl 2‐oxopropanoate) in 7 steps with an overall yield of 18% (__Schemes 1__ and __2__). Key step in this sequence is the highly enantioselective reduction