✦ LIBER ✦

A novel synthesis of carbon-labelled quinolone-3-carboxylic acid antibacterials

✍ Scribed by Richard M. Carr; Derek R. Sutherland

Publisher: John Wiley and Sons
Year: 1994
Tongue: French
Weight: 493 KB
Volume: 34
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580341009

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

3‐lodoquinolones were prepared from the corresponding quinolone‐3‐carboxylic acids by Hunsdiecker‐type iododecarboxylation reactions with lead tetraacetate and iodine. Cyanation of the iodo compounds with mixtures of potassium [^13^C]cyanide and copper (I) iodide, gave [3‐^13^C]cyanoquinolones which on acidic hydrolysis afforded quinolone‐[3‐^13^C]carboxylic acids. In this way, nalidixic acid, an immediate precursor of norfloxacin, and quinolone WIN57273 were labelled with carbon‐13 in the metabolically stable carboxylic acid fragment.

📜 SIMILAR VOLUMES

Regioselective Synthesis of Quinolone An

Regioselective Synthesis of Quinolone Antibacterials via Borate Complex of Quinolone Carboxylic Acid.

✍ Majid M. Heravi; Zeinab S. Jaddi; Hossein A. Oskooie; Shahnaz Khaleghi; Mitra Gh 📂 Article 📅 2006 🏛 John Wiley and Sons ⚖ 17 KB

## Abstract For Abstract see ChemInform Abstract in Full Text.

Antibacterial activity of 6, 8-disubstit

Antibacterial activity of 6, 8-disubstituted-quinolone-3-carboxylic acids

✍ Krishnan, Raghavan (author);Lang, S. A. (author) 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB

Antibacterial activity of 6, 8-disubstit

Antibacterial activity of 6, 8-disubstituted-quinolone-3-carboxylic acids

✍ Krishnan, Raghavan (author);Lang, S. A. (author) 📂 Article 📅 1986 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB

Synthesis and in vitro antibacterial act

Synthesis and in vitro antibacterial activity of some 1 -(difluoromethoxyphenyl)quinolone-3-carboxylic acids

✍ W. Xiao; R. Krishnan; Y.-I Lin; E. F. Delos Santos; N. A. Kuck; R. E. Babine; S. 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 358 KB

An improved synthesis of Carbon-14 label

An improved synthesis of Carbon-14 labelled carboxylic acids from Carbon-14 labelled amino acids

✍ T. V. Ramamurthy; S. Ravi; K. V. Viswanathan 📂 Article 📅 1988 🏛 John Wiley and Sons 🌐 French ⚖ 223 KB 👁 1 views

Various Carbon-I4 l a b e l l e d amino acids i n c l u d i n g t h e a r o m a t i c ones viz., t y r o s i n e , phenylalanine and t r y p t o p h a n are converted t o t h e corresponding c a r b o x y l i c acids i n high y i e l d (70 -9M) on a micromolar scale s y n t h e s i s l y r e a c t i

ChemInform Abstract: Microwave-Assisted

ChemInform Abstract: Microwave-Assisted Amination of Quinolone Carboxylic Acids: An Expeditious Synthesis of Fluoroquinolone Antibacterials.

✍ P. Ganapati Reddy; S. Baskaran 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v