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A novel substrate for analyzing Alzheimer’s disease γ-secretase

✍ Scribed by Stefan F. Lichtenthaler; Gerd Multhaup; Colin L. Masters; Konrad Beyreuther

Book ID
117111023
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
187 KB
Volume
453
Category
Article
ISSN
0014-5793

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Objective: The most common pathogenesis for familial Alzheimer's disease (FAD) involves misprocessing (or alternative processing) of the amyloid precursor protein (APP) by c-secretase due to mutations of the presenilin 1 (PS1) gene. This misprocessing/alternative processing leads to an increase in t