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A novel series of non-nucleoside inhibitors of inosine 5′-monophosphate dehydrogenase with immunosuppressive activity

✍ Scribed by Trevor J Franklin; William P Morris; Vivien N Jacobs; Eric J Culbert; Christine A Heys; Walter H.J Ward; Peter N Cook; Frédéric Jung; Patrick Plé


Book ID
113994506
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
427 KB
Volume
58
Category
Article
ISSN
0006-2952

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Antiproliferative effects of AVN944, a n
✍ Daniel Floryk; Timothy C. Thompson 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 French ⚖ 384 KB

## Abstract Inosine 5‐monophosphate dehydrogenase II, a key enzyme in the __de novo__ synthesis of purine nucleotides, is expressed in prostate tumors and prostate cancer cells. AVN944 is a new, specific, noncompetitive IMPDH inhibitor. In this study, we investigated the effects of IMPDH inhibitor