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A novel regio- and stereoselective synthesis of isoindolines

✍ Scribed by Paivi J. Kukkola; Natalie A. Bilci; Theodore J. Ikeler


Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
209 KB
Volume
37
Category
Article
ISSN
0040-4039

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A regio- and stereoselective synthesis o
✍ Philippe Bayard; LΓ©on Ghosez πŸ“‚ Article πŸ“… 1988 πŸ› Elsevier Science 🌐 French βš– 177 KB

The new activated 2-aza-1,3-dienes 1 are readily prepared by acylation of N-tri-methylsilylimines 3. They react with electrophilic olefins to yield substituted piperidones 4 \_ and 6 with high diastereoselectivity.