A novel peptide from Apis mellifera and solid-phase synthesis of its analogue
β Scribed by Meng, Yu; Yang, Xiao Xiao; Sheng, Yu Xin; Zhang, Jin Lan; Yu, De Quan
- Book ID
- 118427964
- Publisher
- Chinese Electronic Periodical Services
- Year
- 2012
- Tongue
- English
- Weight
- 241 KB
- Volume
- 23
- Category
- Article
- ISSN
- 1001-8417
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## Abstract In this paper we describe the synthesis of chiral peptide nucleic acids (PNAs) 1β3 using SPPS methodologies. Starting material for the monomer units was the commercially available amino acid ornithine. lβ or Dβornithine and the nucleobase thymine were linked by a carboxymethylene spacer
Azido acids were producedfrom et-branchedacids by a-brominationwith NBS followedby 8ub8titution withsodiumazide andthe productswereusedin a novelmethodof solid-phase synthesis. The azido acids were transformedinto the highly activated acid chloridesandused synthesisof extremelyhinderedpeptidescontai