A Novel One-step Synthesis of 3-Substituted 5,6-Dihydrothiazolo[2,3-c]-1,2,4-triazoles and -6,7-Dihydro-5H-1,2,4-triazolo[3,4-b][1,3]thiazines
โ Scribed by T. Wu, M.; G. Payne, L.; A. Patchett, A.
- Book ID
- 118026365
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 1979
- Tongue
- English
- Weight
- 71 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0385-5414
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract 5โฒโMercaptoโ1โฒ__H__โ1,2,4โtriazolโ3โฒโylโisoquinolinium salts **(6)** were synthesised by the reaction of __ortho__โacyl phenylacetones **(2)** or the corresponding pyrylium salts **(3)** and 5โaminoโ2,3โdihydroโ1__H__โ1,2,4โtriazoleโ3โthione **(5)**. Treatment of thioles **6** withฮฑ,ฯโd
The reaction of 3-mercapto-4-aryIideneamino-l,2,4triazoles 2b-d, 3a-d with ethyl bromoacetate and/or phenacyl bromide in hot DMF and triethylamine affords the stereochemically pure 7-acyl-6-aryl-6,7dihydro-5H-lt2, 4-triazolo[3,4-b][l, 3,4]thiadiazines