On triazoles XLIX. Synthesis of 5,6-dihydrothiazolo[3,2-b]-[1,2,4]triazol-2-yl-, 6,7-dihydro-5H-[1,2,4]triazolo[5,1-b][1,3]thiazin-2-yl-, and 5,6,7,8-tetrahydro[1,2,4]triazolo[5,1-b] [1,3]thiazepin-2-yl-isoquinolinium salts

✍ Scribed by Ibolya Prauda; József Reiter

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2003
• Tongue: English
• Weight: 105 KB
• Volume: 40
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570400612

✦ Synopsis

Abstract

5′‐Mercapto‐1′H‐1,2,4‐triazol‐3′‐yl‐isoquinolinium salts (6) were synthesised by the reaction of ortho‐acyl phenylacetones (2) or the corresponding pyrylium salts (3) and 5‐amino‐2,3‐dihydro‐1__H__‐1,2,4‐triazole‐3‐thione (5). Treatment of thioles 6 withα,ω‐dibromoalkanes led to type 15, 16 and 17 isoquinolinium salts condensed with thiazole, thiazine and thiazepine rings. When 6 are reacted with dibromomethane (10) 11 type dimeric structures are obtained.