A novel one pot multi-component strategy for facile synthesis of 5-aryl-[1,2,4]triazolidine-3-thiones
β Scribed by Mane, M.M.; Pore, D.M.
- Book ID
- 126649739
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- French
- Weight
- 345 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A simple and efficient synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones was achieved via a one-pot multi-component reaction of cyclohexyl isocyanide, an aldehyde, a 1,3-dicarbonyl compound, and ammonium acetate in the presence of a catalytic amount of KHSO 4 in acetonitrile.
## Abstract 1β(Aralkyl/aryl)β3β(alkyyaralkyl)β5βaroylβ1,2,3,4βtetrahydropyrimidines (**2aβc**) have been synthesized by dethiomethylation of 5βaroylβ6βmethylthioβ1,2,3,4βtetrahydropyrimidines (**1aβc**). An alternative oneβpot synthetic strategy has been developed for the title compounds **2aβt** b