A novel on-resin synthesis of C-terminally amidated peptides
β Scribed by Kalle Kaljuste; James P. Tam
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- French
- Weight
- 226 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0040-4039
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π SIMILAR VOLUMES
A synthetic strategy which allows for the general modification of peptides at the C-terminus has long been the goal of the synthetic chemist. We report here the full synthetic details of our inversion and modification methodology demonstrating the method with the synthesis of peptide amides, alcohol
The C-terminal amide group is present in several biologically active peptides including deamino-oxytocin, 1 LH\_m;\*'3 and secretin. 4 These peptides have been synthesized by solid phase methods' in which the C-terminal amide of the protected peptide was removed from the resin by amminolysis or tran
## Abstract The standard __p__βMBHA resin used during Bocβchemistry synthesis of peptides carrying __C__βterminal carboxamides is compromised by batchβtoβbatch variations in its performance. This can cause artificially βdifficultβ couplings during peptide chain assembly, which may ultimately lead t
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