✦ LIBER ✦

Internal resin capture — A self purification method for the synthesis of C-terminally modified peptides

✍ Scribed by Michael Davies; Mark Bradley

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 698 KB
Volume: 55
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(99)00146-5

No coin nor oath required. For personal study only.

✦ Synopsis

A synthetic strategy which allows for the general modification of peptides at the C-terminus has long been the goal of the synthetic chemist. We report here the full synthetic details of our inversion and modification methodology demonstrating the method with the synthesis of peptide amides, alcohols, nitriles and a range of other modified peptides.