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A novel mutation of the PTEN gene in a Japanese patient with Cowden syndrome and bilateral breast cancer

โœ Scribed by Genshu Tate; Takao Suzuki; Yutaka Endo; Toshiyuki Mitsuya


Book ID
113513354
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
175 KB
Volume
184
Category
Article
ISSN
0165-4608

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## Abstract Cowden disease (CD) is an autosomal dominant syndrome characterized by multiple hamartomatous lesions and an increased risk for malignancies. Recent evidence has indicated that the PTEN gene, encoding a protein tyrosine phosphatase, is the CD susceptibility gene. However, another line o