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Prevalence and clinical predictors of germline PTEN mutation in endometrial cancer patients with Cowden and Cowden-like syndrome

✍ Scribed by Mahdi, H.; Mester, J.L.; Michener, C.; Eng, C.

Book ID: 126548751
Publisher: Elsevier Science
Year: 2014
Tongue: English
Weight: 71 KB
Volume: 133
Category: Article
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2014.03.209

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Cowden disease (CD) is a rare, autosomal dominant inherited cancer syndrome characterized by multiple benign and malignant lesions in a wide spectrum of tissues. While individuals with CD have an increased risk of breast and thyroid neoplasms, the primary features of CD are hamartomas. The gene for