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A Novel Model of Acetaminophen-Induced Acute Hepatic Failure in Rabbits

โœ Scribed by Tony Manibur Rahman; Angela Clare Selden; Humphrey Julian Francis Hodgson

Book ID
115636702
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
336 KB
Volume
106
Category
Article
ISSN
0022-4804

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An improved model of acetaminophen-induc
An improved model of acetaminophen-induced fulminant hepatic failure in dogs
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We have established an improved model of fulminant hepatic failure in dogs. Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 pg/ml for 20 hr. This regimen produces sever

Acetaminophen-induced fulminant hepatic
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โœ L. Ortega; J. I. Landa Garcia; A. Torres Garcia; G. Silecchia; J. Arenas; A. Sua ๐Ÿ“‚ Article ๐Ÿ“… 1985 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 516 KB

Results concerning morphological and biochemical changes following intravenous administration of different doses of acetaminophen in dogs are reported. Acetaminophen infusion, as a parenteral solution (500 mg per kg per 90 min), produced fulminant hepatitis characterized by a good correlation betwee