A new efficient procedure for the cleavage of aliphatic methyl ethers under the mild conditions by the use of the reagents system, boron tribromide -sodium iodide -15-crown-5 is described.
A novel method of ether cleavage
β Scribed by Raymond D. Youssefyeh; Yehuda Mazur
- Publisher
- Elsevier Science
- Year
- 1962
- Tongue
- French
- Weight
- 144 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
ALTHOUGH ethers have become easily accessible by recently published procedures,' their widespread use a8 a protecting group in alicycllc chemistry &ill awaits satisfactory methodsfor their cleavage to the parent alcohola. The various methods described either use too drastic conditiona or do not lead to the desired alicyclic alcohols.3'4
π SIMILAR VOLUMES
A general and efficient procedure for the cleavage of a cyclic ethers by the use of dimethylboron bromide is described.
An operationally simple, high-yielding and highly chemoselective procedure has been developed for the conversion of benzyl ethers to the corresponding alcohols, using lithium naphthaknide as the reagent. Q 1997 Elsevier Science Ltd.